I think it will be in Arizona. Specifically the CopperState drive. Didn't someone total an Enzo a couple years back? I recall it was the guy who wanted to put the most miles on his Enzo and was driving it all the time.
I think those events (such as Players Run/Bull Run/etc) get people hopped up on getting attention and then they start driving crazy.
Another way of betting on this is how long after the car is for sale before one is totaled. Not that I am looking forward to it, but I like betting... I'm guessing it'll be pretty quickly - like within the first month.
And oh, I am changing my bet for the first wreck from FL to the Middle East. I think the first wreck will be in Dubai. It's hot, with sand blowing on the road. Someone will be wearing sandals and BAM, they'll end up in a sand dune. My side gig is a fortune teller, so I can be pretty specific about details. Or maybe I just have a vivid imagination and a sense of humor!
I am picturing someone in the middle east. A wealthy sheik with a turban on his head. He's ripping along a straight road. A hapless camel walks out. He slams on the brakes. The rear air brake pops up. His turban dislodges and obstructs his vision. He hits the camel, goes in the other lane and is then hit by a rather ornery mule pulling a heavy cart full of something used to keep camels from crossing the roads.
I am pretty sure this will happen. 98.9% confident.